Sample-/gene-dependent normalization factors.Tests of log2 fold change above or below a threshold.Dispersion plot and fitting alternatives.Recommendations for single-cell analysis.Extended section on shrinkage estimators.Control features for estimating size factors.Principal component plot of the samples.Heatmap of the sample-to-sample distances.Data quality assessment by sample clustering and visualization.Effects of transformations on the variance.Rich visualization and reporting of results.Log fold change shrinkage for visualization and ranking.Tximeta for import with automatic metadata.Transcript abundance files and tximport / tximeta.An RNA-seq workflow on the Bioconductor website covers similar material to this vignette but at a slower pace, including the generation of count matrices from FASTQ files. This vignette explains the use of the package and demonstrates typical workflows. The package DESeq2 provides methods to test for differential expression by use of negative binomial generalized linear models the estimates of dispersion and logarithmic fold changes incorporate data-driven prior distributions. An important analysis question is the quantification and statistical inference of systematic changes between conditions, as compared to within-condition variability. Analogous data also arise for other assay types, including comparative ChIP-Seq, HiC, shRNA screening, and mass spectrometry. The count data are presented as a table which reports, for each sample, the number of sequence fragments that have been assigned to each gene. A basic task in the analysis of count data from RNA-seq is the detection of differentially expressed genes.
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A prototype was ready by February 2002 and, with great reviews, the extension was installed by thousands of users daily. StumbleUpon was founded in November 2001 by Garrett Camp, Geoff Smith, Justin LaFrance and Eric Boyd during Camp's time in graduate school at the University of Calgary. Users were able to filter results by type of content and were able to discuss such webpages via virtual communities and were able to rate such webpages via like buttons. StumbleUpon was a browser extension, toolbar, and mobile app with a "Stumble!" button that, when pushed, opened a semi-random website or video that matched the user's interests, similar to a random web search engine. Stunning photography and backgrounds for all of your devices.Information Model for StumbleUpon's user profile Instructablesĭig deeper and find out the truth. Sometimes, it's the little things in life that need improvement. Taste KidĮxplores your tastes and preferences. You probably need a new desktop background. Free RiceĮach questions answered correctly translates to 10 grains of rice donated to a hunger charity. It won't change the world, but you the distraction can be nice, even for a moment. When doing good in the world feels too hard, just vote for good. Sometimes, the sound of rain is soothing. IncrediboxĬreate your own music with just a few clicks. Syncs police scanners from different cities with ambient music. Party CloudĪutomatically syncs music, now you're a DJ. Flash by NightĪ collection of addictive games. HabitRPGĪ habit building app that treats your life like a game. FoddyĪ running game using your keyboard skills. Cookie ClickerĬlick for cookies and level up. Pick a game, share a link to your room, and you're set. This site allows you to upload ROMs (legally obtained, _of course_, unless you're a bad person) and play with friends within your browser. I Need a PromptĪ Pokémon battle simulator to waste hours on. Weave Silkĭraw stunning symmetrical images with the click of a mouse. Suggests books and authors based upon your interests. SleepytimeĪ calculator that tells you exactly when to wake up for a good night's sleep. ![]() Lizard Pointīrowser-based educational activities. HubskiĪ forum of good ideas and conversations. The site has been running since 1997.Įducational Websites 12. Turn on the lights (or a disco ball) in someone's home from your computer. ![]() ![]() Shut Up and Take My MoneyĪ shopping website of stuff you don't need, but you really want. Don't Even ReplyĪ collection of emails from awful people. Shady URLĬhanges URLs to look like viruses. What's the point of this? Yeah, I don't know - just embrace the weird. Pound on your keys and freak out your boss. Generates even more useless sites to waste your time. Find the Invisible CowĪn Internet version of the hiding game Hot and Cold. Or you could sit there and keep refreshing Facebook until something interesting actually happens. So if you prefer procrastination to productivity, this list of 50 websites should keep you amused for a few hours. ![]() SEE ALSO: 8 people confess why they finally deleted social media That requires like actually moving or interacting with other humans. Besides, it's not like you could be doing something constructive at work or maybe, I don't know, go outside. Bored with your usual digital stomping grounds?ĭon't fret, bored friend! There are plenty of sites other than Twitter or Instagram for you to waste countless hours on. ![]() The film does a remarkable effort about contextualizing Ruby's fears and frustrations of being held captive in two different worlds, neither feeling fully accepted or whole, and that's why her embarking on a personal dream that her family can never fully appreciate feels so significant. While she knows sign language and has grown up with these loving figures, she'll still always be the one who's different, the one who hears the insults her family cannot. She wonders if her mother wishes that she too were deaf, and during a heartfelt late-night talk, mom actually admits that upon her daughter's birth she did feel disappointment when Ruby had hearing. ![]() However, within her family, she feels ostracized because she's different. She worries she will forever be defined by her family's disability even if she doesn't share it. To the rest of the school, she's that "deaf family girl," and it's remarked that when she began high school she had an accent reminiscent of what deaf people can sound like, a point that her peers cruelly imitate. She feels ostracized and awkward within her own family and outside of her own family. That's so much pressure to bear for one teenage girl, knowing that she's the link between her family's poverty-treading existence and possibly breaking free into a larger hearing community. She's looked upon as the family interpreter, a position they cannot afford to pay for someone else's services so the duties and responsibilities fall upon her. Ruby isn't just the only member of her family who can hear, she's also their vital lifeline to the outside world. ![]() That's because the movie does an excellent job of establishing these people as characters, establishing the family dynamic as fraught but loving, and establishing a conflict that is direct and clear as far a major point of separation. I do not hold the familiar formula against CODA, even as the family's goal and her personal goal come into direct conflict in sometimes forced manners. It's familiar, but that doesn't mean under the right set of hands that it cannot still be resonant and emotionally gratifying. It's based upon a 2014 French film, The Family Beller, and follows many of the same beats from other sentimental family dramas about sticking out in your family and society, chasing your dream, often in conflict with your family's expectations, gaining that sense of inner strength and resolve, and mending differences in perspective with hard-fought and well-earned wisdom. The framework of CODA is familiar to anyone who has watched a coming-of-age story or family drama, but it's the conviction and strength of character and sheer force of empathy that makes this movie a standout film for 2021. Ruby's music teacher agrees to train her because he believes in her potential, but Ruby has to worry that her dream is something that cannot be shared with the people she loves most, and how would they all get on without her? She's balancing working for her family on their fishing trawler, maintaining good grades in school, and possibly pursuing scholarships to enroll at a music and fine arts college for singing. Her mother (Marlee Matlin) and father (Tony Kotsur) and her older brother (Daniel Durant) are all deaf, and she is the only member of her household with the ability to hear. Ruby Rossi (Emilia Jones) falls under the category of CODA, a Child Of a Deaf Adult. Rating: PG-13 (Strong Sexual Content|Language|Drug Use) Encouraged by her enthusiastic, tough-love choirmaster (Eugenio Derbez) to apply to a prestigious music school, Ruby finds herself torn between the obligations she feels to her family and the pursuit of her own dreams. But when Ruby joins her high school's choir club, she discovers a gift for singing and soon finds herself drawn to her duet partner Miles (Ferdia Walsh-Peelo). Her life revolves around acting as interpreter for her parents (Marlee Matlin, Troy Kotsur) and working on the family's struggling fishing boat every day before school with her father and older brother (Daniel Durant). Seventeen-year-old Ruby (Emilia Jones) is the sole hearing member of a deaf family - a CODA, child of deaf adults. ![]() Do you want to make a little money on the side until or if you wish to turn it into your full-time job? Do you want to be a cam girl for a short period of time or do you want to be really dedicated to it and turn it into your career? To make money on webcam, you will first need to decide what you want to achieve. Whether you wish to become a webcam girl because you have heard about the amazing income or you enjoy the activities of camming, you will need to do your own research and learn everything there is if you wish to be successful and stand out among all the webcam models out there. 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To check whether the server is running or not, click the arrow in the system tray and search for the icon shown in the screenshot. Uncheck Show Readme and click on Finish button as shown in the below screenshot: Next screen is the installation completion screen. In the next screen we can see the installation progress as shown in the below screenshot: Now, click on Next button as shown in the below screenshot: If you don’t see any path, do it manually by clicking on (…) button. In the next screen select the path to Java Virtual Machine (JVM) on your machine which will be automatically done by the setup. Leave it to the default location and click on Install button as shown in the below screenshot: In the next screen we can select the location at which the server will be installed. Also specify a administrator User Name and Password of your choice and click on Next button as shown in the below screenshot: Change the HTTP Connector Port from 8080 to any other value (4040 in the screenshot) to avoid port number collision with Oracle server (default port for Oracle is 8080). Next screen will be the server’s configuration screen. Take care that you have checked all the boxes as shown in the below screenshot and click on Next button: In the next screen you can select different components you want to install. Click on I Agree button as shown in the below screenshot: Next screen is the license agreement screen. ![]() Click on Next button as shown in the below screenshot: The initial screen you will see is the welcome screen for Apache Tomcat server. Note: Before installing Apache Tomcat 8.xx, install JDK7 or later as Tomcat requires path to JRE.ĭouble click apache-tomcat-8.0.15.exe file to start the installation as shown in the below screen shot: In this tutorial I will be installing Apache Tomcat Server 8.0.15 Version. Download Apache Tomcat Server from this link. ![]() ![]() KnowledgeHut reserves the right to cancel or reschedule events in case of insufficient registrations, or if presenters cannot attend due to unforeseen circumstances. The User agrees and covenants not to hold KnowledgeHut and its Affiliates responsible for any and all losses or damages arising from such decision made by them basis the information provided in the course and / or available on the website and/or platform. The User is solely responsible for evaluating the merits and risks associated with use of the information included as part of the content. Nothing contained herein constitutes any representation, solicitation, recommendation, promotion or advertisement on behalf of KnowledgeHut and / or its Affiliates (including but not limited to its subsidiaries, associates, employees, directors, key managerial personnel, consultants, trainers, advisors). The user of this website and/or Platform (User) should not construe any such information as legal, investment, tax, financial or any other advice. I hope you enjoy reading these books and implement the learnings effectively in your Data Science journey.ĭisclaimer: The content on the website and/or Platform is for informational and educational purposes only. They can help you start with and understand the statistics needed to pursue data science, and make better inferences about the data. The books mentioned in this article are the best statistics books for Data Science. And therefore An Introduction to Statistical Learning is one of the best statistics books for Data Science. Whether you are a statistician or a non-statistician, this book helps you use advanced statistical learning techniques to analyse data. The book uses R programming to facilitate the practical implementation of statistical concepts. Some of the topics that are covered in this book are regression, classification, re sampling methods, tree-based methods, support vector machines, clustering etc. Practical Statistics for Data ScientistsĪn Introduction to Statistical Learning gives a feasible overview of statistics, teaching some of the most important modelling techniques along with examples and applications. Yes, the mathematical formulations are important but so is the innate knowledge to use the statistical tools at hand effectively. Sometimes we seek the same kind of learning when we are searching for the best data science courses in India. Naked Statistics can prove to be the best book for statistics and probability for data science for those who believe in learning by understanding intuition rather than mathematical theories. He shows how data can be manipulated and misinterpreted by careless parties, and how the same data is being brilliantly exploited by researchers and experts to answer difficult questions. The author, Wheelan throws light on concepts like inference, regression analysis, and correlation. The book focuses mainly on the underlying intuition behind statistical analysis while stripping away the technicalities. If you slept through your statistics lessons, Naked Statistics can be your champion and lifesaver. ![]() ![]() By trying to protect people that hadn’t asked for her protection by translating around awkward moments, Oliva inadvertently engaged in her own form of paternalism.įor Oliva, translation is a “constellation of many acts” that includes interpretation, interviewing, advocacy, diplomacy, and care. When done well, interpreting should empower folks to advocate for themselves. Interpreters are neutral and translate everything in a room, while advocates take a side and act on behalf of someone. She shields people from the worst comments, before later coming across organizer Roberto Tijerina’s popular curriculum “Interpreting for Social Justice,” in which he outlines the separate goals of interpreters and advocates. Oliva is stuck in the middle, “trying to translate into existence a respect that wasn’t there.” Some volunteers “got off on the sense of emergency” and the “high drama of Helping Others,” offering impractical, unearned, or blunt advice. Volunteers are instructed to call asylum seekers “friends” to avoid legal liability, a term she finds patronizing and overly intimate. A “heritage speaker,” Oliva is often working in groups of three “well-meaning” volunteers, asking strangers to recount traumas and condense whole lives into the 150 words allotted by the I-589.Ī lawyer at the clinic calls this “‘bureaucratic violence,’ the carrying across of people out of their own words, their own language, the mutilation of the stories they tell.” It is “a violence I participated in,” Oliva writes, “even if it was as gentle as I could make it.” She doesn’t leave readers with guilty hand-wringing, however, or offer relenting justifications for her role in the larger system of “government surveillance.” Instead, she delves into the underlying dynamics of the room, offering lessons learned and a path forward. Wanting to focus on something new and to make herself useful, she accepts a friend’s invitation to do translation work at a pro se asylum application clinic in New York. Now a community engagement manager at the National Immigrant Justice Center in Chicago, Oliva’s work in the immigration world began in January 2017, fresh into Trump’s presidency. immigration policies, her personal politics, and those of her fellow translators. ![]() One might also expect a book following migrants’ journeys to closely follow and profile characters in a journalistic fashion, but Oliva takes on a less externally probing role, turning the lens toward U.S. Oliva’s nonfiction debut is sectioned into three parts, “Caminante No Hay Camino,” which explores the river as a metaphor for border crossings and the crossings between languages “Sobremesa,” which delves into Oliva’s experience with language around her family’s dinner table and the tables where she translates for the I-589, the Application for Asylum and Withholding of Removal and “El Azote,” on how the walls of the immigration and carceral systems intersect. Tue 6/27 7 PM, Pilsen Community Books, 1102 W. Within these complexities is where Mexican American translator, immigration advocate, and divinity school graduate Alejandra Oliva focuses her attention in Rivermouth: A Chronicle of Language, Faith, and Migration. Translation can build connections and prompt material change, but it can also exclude and yield toward those with more power. I’ve often described my advocacy and communications work as “translation,” learning a person’s story and molding it into a form-a news article, an op-ed, an action toolkit, or an application-in an attempt to fulfill needs by way of words. Best of Chicago 2022: Sports & Recreation.Best of Chicago 2022: Music & Nightlife. ![]() ![]() In addition to the performance and reliability gains provided by the updated C# extension, C# Dev Kit lets you enjoy these same performance improvements with the solution, debugging, and testing features. Previous Time to IntelliSenseīenchmarked using a 2GB sized solution with 40 projects and 500,000 lines of source code. Both extensions integrate with components like Roslyn and Razor to deliver superb performance for tools such as IntelliSense, definition and symbol navigation, syntax highlighting, refactoring, and code formatting. The C# extension is built on the incredible foundation started with OmniSharp by the amazing OSS community. Experience improved performance and reliabilityĬ# Dev Kit is powered by the recently updated open-source C# extension, now powered by a Language Server Protocol (LSP) Host, also open source. It can also be run via the command palette. The extension will discover and surface your tests in the Test Explorer pane just like for your other languages. With C# Dev Kit, your tests in XUnit, NUnit, MSTest, and bUnit will be discovered and organized for you more easily for fast execution and results navigation. Test your projects with expanded Test Explorer capabilities This lets you quickly add new projects or files via templates to your solutions and easily build all or part of your solution. This addition provides a curated and structured view of your application for effortless, central project management. Manage your projects with a new solution viewĬustomers often praise the power of project management with C#, so like Visual Studio, C# Dev Kit adds a new Solution Explorer view that works alongside the VS Code existing workspace view. The IntelliCode for C# Dev Kit extension (optional), which brings AI-powered development to the editor.C# Dev Kit extension, which builds from the foundations of Visual Studio to provide solution management, templates, and test discovery/debugging.The C# extension, which provides base language services support and continues to be maintained independent of this effort.As shown in the graphic below, C# Dev Kit consists of: The C# Dev Kit consists of a set of VS Code extensions that work together to provide a rich C# editing experience, AI-powered development, solution management, and integrated testing. This ensures a great experience whether you are quickly editing a C# file, learning C#, or debugging a backend API. Try out C# Dev Kit for your C# web and cloud-native projects and share your feedback today!Ĭ# Dev Kit borrows some familiar concepts from Visual Studio to bring a more productive and reliable C# experience to VS Code. The source repo for this extension is in the process of being migrated and will be available later this week. It works together with the C# extension, which has been updated to be powered by a new fully open-source Language Server Protocol (LSP) host, creating a performant, extensible, and flexible tooling environment that easily integrates new experiences into C# for VS Code. ![]() ![]() The C# Dev Kit is designed to enhance your C# productivity when you’re working in VS Code. We are thrilled to announce the preview release of C# Dev Kit, a new Visual Studio Code extension that brings an improved editor-first C# development experience to Linux, macOS, and Windows. What makes acquiring new items especially interesting though is that most are portrayed as boons from the gods and so which you take with you affects your relationship with your would-be peers and can open up otherwise hidden side quests. Whether you want to emphasise speed, defence, attack, or the use of a particular weapon depends on both your natural playstyle and which boss character you’re currently having trouble with, but rarely has a loadout mattered so much outside of a hardcore role-playing game. It does not store any personal data.You quickly build up a wide variety of different moves and buffs, that at first you’ll just pick and choose largely at random, before subsequent runs reveal how they can all work together to make you considerably more powerful than with a less optimised set-up. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". ![]() These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. Hades is a hack n slash with a forever changing dark twist. If you like your RPG’s, dark and unforgiving dungeons to smash your way through then Hades is a definite must play for you. Originally released on PC and Switch last year (2020) and is now a free to play title with Xbox Game Pass. This keeps the gameplay refreshing, unique and certainly stopped me from placing the controller down in frustration. This procedural life and death changing of the game also expands on the narrative of play as well as any help NPC’s can offer. This may also see that the path you took prior to your untimely death is closed off. The game is built, knowing that you’e likely to perish often in any given bout against hordes of nasties, so upon any revival another path, an additional area will open up. Like any good dungeon crawler there’s a lot of goodies to be discovered as well as secret areas.ĭying in the Underworld can be a painful experience on one’s progress for sure, however, it can also be beneficial. Likewise you can use your loot to up your skills and weaponry. Or use your ill-found treasures to, er, bribe your fortune towards your escape. But die (and you will) you’re placed back at the beginning. Guided and aided by other Gods and underworld characters you will loot and slash through varying parts of Hade’s dark kingdom. ![]() ![]() You are Zagreus, the son of Hades on a mission to escape the underworld in this dark humoured dungeon crawler rogue-like title from Supergiant Games.Ī semi-cell shaded hack n slash pits you up against Hades finest demons and monsters as you cut your way to Mount Olympus. The eternally cursed, the cries of the tortured, the infinite spiralling damnation of trapped souls gets a bit boring – there’s got to be more out there. ![]() Whether planning to encrypt entire volumes, removable devices, or individual files, Windows 11 and Windows 10 meet these needs by providing streamlined, usable solutions. This situation is especially true for data protection, and that's a scenario that organizations need to avoid. Every time there's a possible delay or difficulty because of a security feature, there's a strong likelihood that users will try to bypass security. The best type of security measures is transparent to the user during implementation and use. Modern Windows devices are increasingly protected with BitLocker Device Encryption out of the box and support SSO to help protect the BitLocker encryption keys from cold boot attacks. Users need to enter a PIN to start the PC, and then their password to sign in to Windows. ![]() Used Space Only encryption in BitLocker To Go allows users to encrypt removable data drives in seconds.īitLocker could require users to enter a recovery key when system configuration changes occur.īitLocker requires the user to enter a recovery key only when disk corruption occurs or when the PIN or password is lost. There's no support for using BitLocker with self-encrypting drives (SEDs).īitLocker supports offloading encryption to encrypted hard drives.Īdministrators have to use separate tools to manage encrypted hard drives.īitLocker supports encrypted hard drives with onboard encryption hardware built in, which allows administrators to use the familiar BitLocker administrative tools to manage them.Įncrypting a new flash drive can take more than 20 minutes. When BitLocker is enabled, the provisioning process can take several hours.īitLocker pre-provisioning, encrypting hard drives, and Used Space Only encryption allow administrators to enable BitLocker quickly on new computers. Network Unlock allows PCs to start automatically when connected to the internal network. Modern Windows devices are increasingly protected with BitLocker Device Encryption out of the box and support SSO to seamlessly protect the BitLocker encryption keys from cold boot attacks. When BitLocker is used with a PIN to protect startup, PCs such as kiosks can't be restarted remotely. The below table lists specific data-protection concerns and how they're addressed in Windows 11, Windows 10, and Windows 7. Data Protection in Windows 11, Windows 10, and Windows 7 Windows consistently improves data protection by improving existing options and providing new strategies. More recently, BitLocker has provided encryption for full drives and portable drives. Windows has a long history of providing at-rest data-protection solutions that guard against nefarious attackers, beginning with the Encrypting File System in the Windows 2000 operating system. Wherever confidential data is stored, it must be protected against unauthorized access. When users travel, their organization's confidential data goes with them. See BitLocker for a general overview and list of articles. This article explains how BitLocker Device Encryption can help protect data on devices running Windows. |
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